Nieuws broccoli


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Hoe sulforafaan in koolsoorten effect op kanker, hersenen en hart heeft


Broccoli extract kan beschermen tegen herhaling van mondkanker

Een studie door de Universiteit van het Pittsburgh Cancer Institute, partner met UPMC CancerCenter bevestigt de voorlopige resultaten vorig jaar gepresenteerd op de American Association for Cancer Research Annual Meeting dat krachtige dosissen van broccoli extract een ontgiftings gen activeren dat recidieve hoofd- en halskanker kan verhelpen.

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Ontdekking helpt wetenschappers wellicht om de kankerwerend kracht van broccoli sneller aan te tonen

Een onderzoek van een universiteit van Illinois heeft voor het eerst laten zien dat sulforaphane, de krachtige kankerbestrijder in broccoli, gemaakt en door het lichaam opgenomen kan worden uit basis bacteriŽn in de darm. “Deze ontdekking vergroot de kans dat we in staat zullen zijn deze kankerremmende werking van broccoli in de dikke darm te verbeteren”, stelt Elizabeth Jeffery, een U en I hoogleraar menselijke voeding. “Het is ook bemoedigend, omdat veel mensen hun broccoli te gaar koken, zonder te weten dat ze daarmee planten enzyme vernietigen, die sulforaphane aanmaken. Nu weten we dat micro organisme in onze voeding sommige kankervoorkomende stoffen kunnen aanmaken”, zegt ze.

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Pieter Tau


Anti-kanker effecten van een ingredient van broccoli wordt uitgelegd

Er is licht geschenen op de interactie tussen consumptie van broccoli en verlaagde kans op prostaatkanker. Onderzoekers, die schrijven in de vrij toegankelijke journal "Molecular Cancer" van "BioMed Central", hebben ontdekt dat sulforafaan, een stof in broccoli, een wisselwerking aan gaat met cellen die een gen, genaamd PTEN, missen en zo de kans op de ontwikkeling van prostaatkanker verlagen.

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Cindy Oppers


Broccoli en kool beschermen tegen hartziektes

Broccoli is niet zomaar een groente die gegeten moet worden om aan de gewenste 'vijf stuks groentes en vruchten per dag' te komen, zo meldt de Sunday Telegraph. Wie broccoli eet, krijgt een beschermende laag aan de binnenkant van de slagaders en dat wil zeggen dat de kans op het dichtslibben van die aders, en dus op hartziektes, kleiner wordt. Bloemkool en andere koolsoorten hebben hetzelfde effect.

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Johan


Broccoli may lower lung cancer risk in smokers

The cancer preventive properties of broccoli and other cruciferous vegetables appear to work specifically in smokers, according to data presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

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COPD? Eat Your Veggies.

You know it’s good for you in other ways, but could eating your broccoli also help patients with chronic lung disease? It just might. According to recent research from Johns Hopkins Medical School, a decrease in lung concentrations of NRF2-dependent antioxidants, key components of the lung’s defense system against inflammatory injury, is linked to the severity of chronic obstructive pulmonary disease (COPD) in smokers. Broccoli is known to contain a compound that prevents the degradation of NFRP. The findings were published in the second issue for September of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.COPD is the fourth-leading cause of death in the U.S. and affects more than 16 million Americans. In this study, researchers examined tissue samples from the lungs of smokers with and without COPD to determine if there were differences in measured levels of NRF2 expression and the level of its biochemical regulators, including KEAP1, which inhibits NRF2, and DJ-1, which stabilizes it. Dr. Biswal had previously shown that disruption in NRF2 expression in mice exposed to cigarette smoke caused early onset of severe emphysema. When compared to non-COPD lungs, the lungs of patients with COPD showed markedly decreased levels of NRF2-dependent antioxidants, increased oxidative stress markers, a significant decrease in NRF2 protein with no change in NRF2 mRNA levels (indicating that it was expressed, but subsequently degraded), and similar KEAP1 levels, but a marked decrease in the level of DJ-1. “NRF2-dependent antioxidants and DJ-1 expression was negatively associated with severity of COPD,” wrote principle investigator, Shyam Biswal, Ph.D., an associate professor in the Bloomberg School’s Department of Environmental Health Sciences and Division of Pulmonary and Critical Care at the Johns Hopkins School of Medicine. “Therapy directed toward enhancing NRF2-regulated antioxidants may be a novel strategy for attenuating the effects of oxidative stress in the pathogenesis of COPD.”

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Daily Dose of Broccoli Halts Ulcers and Cancer

Eating just a few ounces of broccoli each day may significantly reduce a person's risk of ulcers and stomach cancer, researchers from Johns Hopkins University have found

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Broccoli may help protect against respiratory conditions like asthma

Here's another reason to eat your broccoli: UCLA researchers report that a naturally occurring compound found in broccoli and other cruciferous vegetables may help protect against respiratory inflammation that causes conditions like asthma, allergic rhinitis and chronic obstructive pulmonary disease. Published in the March edition of the journal Clinical Immunology, the research shows that sulforaphane, a chemical in broccoli, triggers an increase of antioxidant enzymes in the human airway that offers protection against the onslaught of free radicals that we breathe in every day in polluted air, pollen, diesel exhaust and tobacco smoke. A supercharged form of oxygen, free radicals can cause oxidative tissue damage, which leads to inflammation and respiratory conditions like asthma. "This is one of the first studies showing that broccoli sprouts — a readily available food source — offered potent biologic effects in stimulating an antioxidant response in humans," said Dr. Marc Riedl, the study's principal investigator and an assistant professor of clinical immunology and allergy at the David Geffen School of Medicine at UCLA. "We found a two- to three-fold increase in antioxidant enzymes in the nasal airway cells of study participants who had eaten a preparation of broccoli sprouts," Riedl said. "This strategy may offer protection against inflammatory processes and could lead to potential treatments for a variety of respiratory conditions."

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Worried About Skin Cancer?

Rubbing an extract made from broccoli sprouts on your skin may help you to prevent skin cancer, according to Johns Hopkins researchers

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Extract of broccoli sprouts may protect against bladder cancer

A concentrated extract of freeze dried broccoli sprouts cut development of bladder tumors in an animal model by more than half, according to a report in the March 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

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UCLA study finds that broccoli may help boost the aging immune system

The study findings show that sulforaphane, a chemical in broccoli, switches on a set of antioxidant genes and enzymes in specific immune cells, which then combat the injurious effects of molecules known as free radicals that can damage cells and lead to disease.

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Broccoli and the Blood Brain Barrier

As if there weren't enough reasons to eat your vegetables, this week Zhao et al. report that a substance in broccoli helps to maintain the integrity of the blood-brain barrier (BBB) following a cortical contusion injury. Systemic administration of sulforaphane, contained in broccoli and other cruciferous vegetables, increased activity of NF-E2-related factor-2 (Nrf2). Nrf2 binds to the antioxidant response element (ARE), influencing expression of so-called cytoprotective proteins. Sulforaphane treatment of uninjured and brain-injured rats increased cortical expression of Nrf2-driven genes. Infusion of NR decoy oligonucleotides containing the ARE binding site for Nrf2 prevented sulforaphane-induced, Nrf2-driven gene expression. Tight junction proteins are key to maintaining BBB integrity, and they decline after brain injury. Sulforaphane attenuated the loss of these proteins as well as the loss of endothelial cells and also reduced the injury-related increase in BBB permeability and brain edema. OK, OK, pass the broccoli.

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Broccoli Sprout-Derived Extract Protects against Ultraviolet Radiation

A team of Johns Hopkins scientists reports in this week’s issue of the Proceedings of the National Academy of Sciences that humans can be protected against the damaging effects of ultraviolet (UV) radiation - the most abundant cancer-causing agent in our environment - by topical application of an extract of broccoli sprouts.

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