Broccoli onder de aandacht nu er een nieuwe stof tegen
diabetes geïdentificeerd is
Onderzoekers hebben een anti-oxidant geïdentificeerd die
rijkelijk voorkomt in broccoli, als een nieuw antidiabeticum. Een
studie met patiënten toont significant lagere bloedsuikerwaarden aan
bij deelnemers die een broccoli-extract aten met hoge doses
sulforafaan. “Er zijn sterke aanwijzingen dat dit een waardevolle toevoeging
op bestaande medicatie kan worden” zegt Anders Rosengren, docent in
metabolisme-fysiologie aan de University of Gothenburg.
Hoe sulforafaan in koolsoorten effect op kanker, hersenen
en hart heeft
Broccoli extract kan beschermen tegen herhaling van mondkanker
Een studie door de Universiteit van het Pittsburgh Cancer
Institute, partner met UPMC CancerCenter bevestigt de voorlopige
resultaten vorig jaar gepresenteerd op de American Association for
Cancer Research Annual Meeting dat krachtige dosissen van broccoli
extract een ontgiftings gen activeren dat recidieve hoofd- en
halskanker kan verhelpen.
Ontdekking helpt wetenschappers
wellicht om de kankerwerend kracht van broccoli sneller aan te tonen
Een onderzoek van een universiteit van
Illinois heeft voor het eerst laten zien dat sulforaphane, de krachtige kankerbestrijder
in broccoli, gemaakt en door het lichaam opgenomen kan worden uit basis bacteriën in de
darm. “Deze ontdekking vergroot de kans dat we in staat zullen zijn deze
kankerremmende werking van broccoli in de dikke darm te verbeteren”, stelt Elizabeth
Jeffery, een U en I hoogleraar menselijke voeding. “Het is ook bemoedigend, omdat
veel mensen hun broccoli te gaar koken, zonder te weten dat ze daarmee planten enzyme
vernietigen, die sulforaphane aanmaken. Nu weten we dat micro organisme in onze voeding
sommige kankervoorkomende stoffen kunnen aanmaken”, zegt ze.
Anti-kanker effecten van een
ingredient van broccoli wordt uitgelegd
Er is licht geschenen op de interactie
tussen consumptie van broccoli en verlaagde kans op prostaatkanker. Onderzoekers, die
schrijven in de vrij toegankelijke journal "Molecular Cancer" van "BioMed
Central", hebben ontdekt dat sulforafaan, een stof in broccoli, een wisselwerking aan
gaat met cellen die een gen, genaamd PTEN, missen en zo de kans op de ontwikkeling van
prostaatkanker verlagen.
Broccoli is niet zomaar een groente die
gegeten moet worden om aan de gewenste 'vijf stuks groentes en vruchten per dag' te komen,
zo meldt de Sunday Telegraph. Wie broccoli eet, krijgt een beschermende laag aan de
binnenkant van de slagaders en dat wil zeggen dat de kans op het dichtslibben van die
aders, en dus op hartziektes, kleiner wordt. Bloemkool en andere koolsoorten hebben
hetzelfde effect.
The cancer preventive properties of broccoli and other cruciferous vegetables appear to
work specifically in smokers, according to data presented at the American Association for
Cancer Research's Seventh Annual International Conference on Frontiers in Cancer
Prevention Research.
You know it’s good for you in other ways, but could eating your broccoli also help
patients with chronic lung disease? It just might. According to recent research from Johns
Hopkins Medical School, a decrease in lung concentrations of NRF2-dependent antioxidants,
key components of the lung’s defense system against inflammatory injury, is linked to
the severity of chronic obstructive pulmonary disease (COPD) in smokers. Broccoli is known
to contain a compound that prevents the degradation of NFRP. The findings were published
in the second issue for September of the American Journal of Respiratory and Critical Care
Medicine, published by the American Thoracic Society.COPD is the fourth-leading cause of
death in the U.S. and affects more than 16 million Americans. In this study, researchers
examined tissue samples from the lungs of smokers with and without COPD to determine if
there were differences in measured levels of NRF2 expression and the level of its
biochemical regulators, including KEAP1, which inhibits NRF2, and DJ-1, which stabilizes
it. Dr. Biswal had previously shown that disruption in NRF2 expression in mice exposed to
cigarette smoke caused early onset of severe emphysema. When compared to non-COPD lungs,
the lungs of patients with COPD showed markedly decreased levels of NRF2-dependent
antioxidants, increased oxidative stress markers, a significant decrease in NRF2 protein
with no change in NRF2 mRNA levels (indicating that it was expressed, but subsequently
degraded), and similar KEAP1 levels, but a marked decrease in the level of DJ-1.
“NRF2-dependent antioxidants and DJ-1 expression was negatively associated with
severity of COPD,” wrote principle investigator, Shyam Biswal, Ph.D., an associate
professor in the Bloomberg School’s Department of Environmental Health Sciences and
Division of Pulmonary and Critical Care at the Johns Hopkins School of Medicine.
“Therapy directed toward enhancing NRF2-regulated antioxidants may be a novel
strategy for attenuating the effects of oxidative stress in the pathogenesis of
COPD.”
Eating just a few ounces of broccoli each day may significantly reduce a person's risk of
ulcers and stomach cancer, researchers from Johns Hopkins University have found
Broccoli may help protect against
respiratory conditions like asthma
Here's another reason to eat your broccoli: UCLA researchers report that a naturally
occurring compound found in broccoli and other cruciferous vegetables may help protect
against respiratory inflammation that causes conditions like asthma, allergic rhinitis and
chronic obstructive pulmonary disease. Published in the March edition of the journal
Clinical Immunology, the research shows that sulforaphane, a chemical in broccoli,
triggers an increase of antioxidant enzymes in the human airway that offers protection
against the onslaught of free radicals that we breathe in every day in polluted air,
pollen, diesel exhaust and tobacco smoke. A supercharged form of oxygen, free radicals can
cause oxidative tissue damage, which leads to inflammation and respiratory conditions like
asthma. "This is one of the first studies showing that broccoli sprouts — a
readily available food source — offered potent biologic effects in stimulating an
antioxidant response in humans," said Dr. Marc Riedl, the study's principal
investigator and an assistant professor of clinical immunology and allergy at the David
Geffen School of Medicine at UCLA. "We found a two- to three-fold increase in
antioxidant enzymes in the nasal airway cells of study participants who had eaten a
preparation of broccoli sprouts," Riedl said. "This strategy may offer
protection against inflammatory processes and could lead to potential treatments for a
variety of respiratory conditions."
Extract of broccoli sprouts may
protect against bladder cancer
A concentrated extract of freeze dried broccoli sprouts cut development of bladder tumors
in an animal model by more than half, according to a report in the March 1 issue of Cancer
Research, a journal of the American Association for Cancer Research.
UCLA study finds that broccoli may
help boost the aging immune system
The study findings show that sulforaphane, a chemical in broccoli, switches on a set of
antioxidant genes and enzymes in specific immune cells, which then combat the injurious
effects of molecules known as free radicals that can damage cells and lead to disease.
As if there weren't enough reasons to eat your vegetables, this week Zhao et al. report
that a substance in broccoli helps to maintain the integrity of the blood-brain barrier
(BBB) following a cortical contusion injury. Systemic administration of sulforaphane,
contained in broccoli and other cruciferous vegetables, increased activity of
NF-E2-related factor-2 (Nrf2). Nrf2 binds to the antioxidant response element (ARE),
influencing expression of so-called cytoprotective proteins. Sulforaphane treatment of
uninjured and brain-injured rats increased cortical expression of Nrf2-driven genes.
Infusion of NR decoy oligonucleotides containing the ARE binding site for Nrf2 prevented
sulforaphane-induced, Nrf2-driven gene expression. Tight junction proteins are key to
maintaining BBB integrity, and they decline after brain injury. Sulforaphane attenuated
the loss of these proteins as well as the loss of endothelial cells and also reduced the
injury-related increase in BBB permeability and brain edema. OK, OK, pass the broccoli.
Broccoli Sprout-Derived Extract
Protects against Ultraviolet Radiation
A team of Johns Hopkins scientists reports in this week’s issue of the Proceedings of
the National Academy of Sciences that humans can be protected against the damaging effects
of ultraviolet (UV) radiation - the most abundant cancer-causing agent in our environment
- by topical application of an extract of broccoli sprouts.
