Nieuws oestrogeen

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Onderzoek helpt de rol van oestrogeen in het geheugen te deconstrueren

UWM onderzoeker onthult nieuwe details over de mechanismen van de receptor.

Het verlies van oestrogenen tijdens de menopauze verhoogt bij de vrouw het risico op dementie en de ziekte van Alzheimer, maar hormoon vervangende therapie kan schadelijke bijwerkingen veroorzaken.

Het kennen van het exacte mechanisme van oestrogeen activatie in de hersenen kan helpen om geneesmiddelen te ontwikkelen die ervoor kunnen zorgen dat vrouwen van middelbare leeftijd de voordelen hebben van hormoonvervangende therapie zonder de risicoverhoging op het krijgen van hart- en vaatziekten of borstkanker.

In een nieuwe studie onthult Karyn Frick, hoogleraar psychologie aan de University of Wisconsin-Milwaukee (UWM), details over de rol van oestrogeen in de complexe cellulaire communicatiesysteem onderliggende geheugenvorming.

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Estrogen Use and Aggressive Cancer

Dr. James G. Schwade reports on a possible new link between estrogen use and the activation or aggravation of certain types of aggressive cancer.

Revealing estrogen's secret role in obesity

Research on the effects of the female sex hormone estrogen in the brain lend credence to what many women have suspected about the hormonal changes that accompany aging: Menopause can make you fat. In animal experiments, researchers showed how estrogen receptors in the brain serve as a master switch to control food intake, energy expenditure and body fat distribution. The study will be presented in August at the American Chemical Society national meeting in Boston.

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New link between estrogen and breast cancer

the female sex hormone estrogen turns on a gene linked to breast cancer, according to new research by Brisbane scientists. The cancer biology team from UQ's Diamantina Institute for Cancer, Immunology and Metabolic Medicine, believe their finding will help explain the link between breast cancer and high levels of estrogen. “What we've shown is that the ability of estrogen to switch this gene on is important for the growth of breast cancer cells,” Diamantina cancer biology research leader Professor Tom Gonda said. The gene they studied, known as MYB, is found in about 70 percent of all breast cancers and is one of several dozen genes called oncogenes that promote cancer growth. “What's important in breast cancer is the ability of estrogen to turn on MYB rather than there being a mutation in the gene itself,” Professor Gonda said.

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Improved estrogen reception may sharpen fuzzy memory

Finding ways to boost the brain's estrogen receptors may be an alternative to adding estrogen to the body in efforts to improve cognition in postmenopausal women and younger women with low estrogen levels, according to neuroscientists at the University of Florida's McKnight Brain Institute.

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Estrogen therapy could be dangerous for women with existing heart risk

Hormone therapy could accentuate certain pre-existing heart disease risk factors and a heart health evaluation should become the norm when considering estrogen replacement, new research suggests. The research also showed that in women without existing atherosclerosis, hormone therapy use included some positive effects on lipids but also some negative effects related to heart health, said MaryFran Sowers, lead researcher and professor of epidemiology at the University of Michigan School of Public Health. The U-M study came about, Sowers said, in trying to explain what's behind the so-called timing hypothesis. The timing hypothesis suggests that if a woman implements a hormone therapy program within six years of her final menstrual period, this narrow window is enough to deter heart disease from developing with the onset of menopause. But the U-M findings suggest that explanation isn't quite so simple, Sowers said. Even within the six-year window, there were negative aspects related to heart disease. While the positive outcomes on HDL and LDL cholesterol levels were observed, Sowers said, researchers also saw negative outcomes in terms of the inflammation process—which can be related to heart disease.

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Hormone eases psychotic symptoms

Australian scientists found that women given the sex hormone oestrogen were less likely to report suffering hallucinations or delusions.

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Estrogen is important for bone health in men as well as women

Although women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at Washington University School of Medicine in St. Louis has shown that low amounts of active estrogen metabolites also can increase the risk of osteoporosis in men.

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Strain Differences and the Response to Estrogens

Studies of low-dose effects of xenoestrogens have yielded conflicting results that may be attributed to differences in estrogen sensitivity between rodent strains. Perinatal exposure of CD-1 mice to low doses of the xenoestrogen bisphenol A (BPA) alters peripubertal mammary gland development. Future studies of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. Wadia et al. (p. 592) examined whether the mammary glands of CD-1 and C57Bl6 mice exhibited similar responses to 17?-estradiol (E2) and whether perinatal exposure to BPA equally enhanced sensitivity of the mammary glands to E2 at puberty.

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Estrogens Shield Breast Cancer Cells

Among the more insidious aspects of cancer is its capacity for escaping the anticancer defenses of the host. New research suggests that some estrogens may further reinforce this evasion of host immunity, even as those same hormones stimulate the growth and spread of hormone-responsive cancers. According to David Shapiro, a medical and biochemistry professor at the University of Illinois at Urbana–Champaign, the new findings highlight the role that estrogen-related interference with immune cell function may play in the development and progression of breast cancer.

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Study Describes Action of Estrogen in Protecting Bone

Researchers at the University at Buffalo have described a novel pathway by which estradiol, the primary estrogen in humans, aids in maintaining bone density, a function critical to avoiding osteoporosis.It is well known that estrogen is essential for healthy bone, and that when the production of estrogen is reduced, as occurs normally in postmenopausal women and pathogenically after exposure to radiation or chemotherapeutic drugs, bones become brittle and break easily. However, the mechanisms involved aren't clearly understood. The new study found that one way estradiol helps to maintain bone density is by stopping the activation of an enzyme known as caspase-3. Also called the executioner caspase, caspase-3 is the central player in initiating the process of apoptosis, or programmed cell death of osteoblasts, the bone cells that aid in the growth and development of new bone and teeth.

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Estrogen Use Before 65 Linked to Reduced Risk of Alzheimer’s Disease

Women who use hormone therapy before the age of 65 could cut their risk of developing Alzheimer’s disease or dementia. This possibility is raised by research that will be presented at the American Academy of Neurology’s 59th Annual Meeting in Boston. The study found women who used any form of estrogen hormone therapy before the age of 65 were nearly 50 percent less likely to develop Alzheimer’s disease or dementia than women who did not use hormone therapy before age 65.

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